Research ArticlePharmacology

Quinone Oxidoreductase-2–Mediated Prodrug Cancer Therapy

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Science Translational Medicine  14 Jul 2010:
Vol. 2, Issue 40, pp. 40ra50
DOI: 10.1126/scitranslmed.3000615

Article Information

vol. 2 no. 40 40ra50

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication November 10, 2009
  • Accepted for publication June 25, 2010
  • .

Author Information

  1. Mark R. Middleton1,*,
  2. Richard Knox2,
  3. Emma Cattell1,
  4. Udo Oppermann3,4,
  5. Rachel Midgley5,
  6. Raghib Ali5,
  7. Tim Auton2,
  8. Roshan Agarwal6,
  9. David Anderson5,
  10. Debashis Sarker6,
  11. Ian Judson6,
  12. Tsuyoshi Osawa7,
  13. Victoria J. Spanswick7,
  14. Scot Davies8,
  15. John A. Hartley7 and
  16. David J. Kerr5,9
  1. 1Department of Medical Oncology, Churchill Hospital, Headington, Oxford OX3 7LJ, UK.
  2. 2BTG, 5 Fleet Place, London EC4M 7RD, UK.
  3. 3Structural Genomics Consortium, University of Oxford, Old Road Campus, Oxford OX3 7DQ, UK.
  4. 4Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, National Institute for Health Research Biomedical Research Unit, Oxford OX3 7LD, UK.
  5. 5Department of Clinical Pharmacology, University of Oxford, Headington, Oxford OX3 7DQ, UK.
  6. 6Drug Development Unit, Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, UK.
  7. 7Cancer Research UK Drug-DNA Interactions Research Group, UCL Cancer Institute, University College London, Paul O’Gorman Building, 72 Huntley Street, London WC1E 6BT, UK.
  8. 8Drug Development Office, Cancer Research UK, 61 Lincoln’s Inn Fields, London WC2A 3PX, UK.
  9. 9SIDRA Medical and Research Centre, P.O. Box 26999, Doha, Qatar.
  1. *To whom correspondence should be addressed. E-mail: mark.middleton{at}medonc.ox.ac.uk

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