14 July 2010
Vol 2, Issue 40
  • Contents

    • Editorial

      • Something in Common

        Participants in the first Sage Commons Congress took crucial steps toward achieving their vision of a world wherein massive aggregates and open sharing of data drive the development of effective therapies.

    • Commentary

      • The Demographic and Biomedical Case for Late-Life Interventions in Aging

        A global research agenda to slow or arrest the effects of biological aging has the potential to avert enormous economic, social, and human costs.

    • Research Articles

    • Editors' Choice

      • Precious Metals

        Copper chelation specifically enhances the sensitivity of cancer cells to platinum-based chemotherapy.

      • Nesfatin-1: Of Mice and Men

        A newly described adipokine that promotes anorexia is found in adipose tissue and is up-regulated by a high-fat diet and inflammation.

      • Imaging the Host Immune Response

        Detecting an enzyme expressed by a subset of monocytes confers an ability to monitor rejection of transplanted hearts.

About The Cover

Cover image expansion

ONLINE COVER . Mosquito-delivered vaccination. Tropical countries are anxious to find a way to prevent malaria, a destructive disease carried by mosquitoes infected with the Plasmodium parasite. Ongoing efforts to develop a conventional vaccine may ultimately be successful, but an alternative approach could bypass some practical difficulties by harnessing the mosquito itself to deliver the immunogen. In malaria-infected mice that also receive certain antibiotics, the parasite multiplies in the liver as usual but the resulting organisms are noninfectious. When these attenuated parasites are released into the blood, they act as a natural inoculation that protects against infection for months afterwards. (See the Research Article by Friesen et al. ). [CREDIT: DENNIS KUNKEL/MICROSCOPY, INC./VISUALS UNLIMITED]