Contents
Vol 2, Issue 40
Contents
Editorial
- Something in Common
Participants in the first Sage Commons Congress took crucial steps toward achieving their vision of a world wherein massive aggregates and open sharing of data drive the development of effective therapies.
Commentary
- The Demographic and Biomedical Case for Late-Life Interventions in Aging
A global research agenda to slow or arrest the effects of biological aging has the potential to avert enormous economic, social, and human costs.
Research Articles
- Natural Immunization Against Malaria: Causal Prophylaxis with Antibiotics
Malaria-infected mice treated with antibiotics remain healthy and are protected against subsequent malaria infection.
- Quinone Oxidoreductase-2–Mediated Prodrug Cancer Therapy
An oxidoreductase enzyme, abundant in tumors, can be catalytically activated by a synthetic cofactor to convert a prodrug to a cytotoxic DNA binding species in human subjects.
Editors' Choice
- Precious Metals
Copper chelation specifically enhances the sensitivity of cancer cells to platinum-based chemotherapy.
- Nesfatin-1: Of Mice and Men
A newly described adipokine that promotes anorexia is found in adipose tissue and is up-regulated by a high-fat diet and inflammation.
- Taking Advantage of What You Know About Complex Diseases
Bayesian analysis approaches offer a useful way to incorporate prior knowledge into existing data analyses through the prior distribution.
- Imaging the Host Immune Response
Detecting an enzyme expressed by a subset of monocytes confers an ability to monitor rejection of transplanted hearts.
