PerspectiveSuccess in Translational Medicine

Twenty-Five Years of Translational Medicine in Antiretroviral Therapy: Promises to Keep

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Science Translational Medicine  07 Jul 2010:
Vol. 2, Issue 39, pp. 39ps33
DOI: 10.1126/scitranslmed.3000749

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The year 2010 marks the 25th anniversary of modern antiretroviral drug discovery and development. In the early 1980s, AIDS was almost always a lethal disease with an appalling clinical course characterized by severe opportunistic infections and unusual forms of cancer. Since that time, starting with zidovudine (AZT) and related 2′,3′-dideoxynucleosides, the causative retrovirus, now called HIV-1, went from being an untreatable infectious agent to being the target of highly active antiretroviral therapy (HAART). This degree of progress refuted early prophesies of therapeutic futility and represents a striking example of translational medicine. Here I review foundational discoveries and events in HIV-1/AIDS research and explore lessons for future translational medicine efforts.


  • Citation: S. Broder, Twenty-five years of translational medicine in antiretroviral therapy: Promises to keep. Sci. Transl. Med. 2, 39ps33 (2010).

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