07 July 2010
Vol 2, Issue 39

About The Cover

Cover image expansion

ONLINE COVER A Trace of Success. Depicted are the changes in U.S. annual death rates due to AIDS among individuals 25 to 44 years of age from 1987–2006. In the 1980s, AIDS was almost always a lethal disease. Since then, the causative retrovirus, HIV-1, went from being an untreatable infectious agent to being the target of highly active antiretroviral therapy (HAART). In honor of the 25th anniversary of modern antiretroviral drug discovery, this week's Perspective by Broder reviews the foundational discoveries and events in HIV-1/AIDS research and explores lessons for future translational medicine efforts. Data are from the U.S. Centers for Disease Control. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]