Contents
Vol 2, Issue 38
Contents
Editorial
- Qualifying Therapeutic Discovery Project Tax Credit
The U.S. Patient Protection and Affordable Care Act includes an opportunity for small life sciences companies to earn tax credits for research and development activities or exchange these credits for grants.
Commentary
- Offering Individual Genetic Research Results: Context Matters
Beyond a fundamental duty to rescue, a one-size-fits-all threshold cannot be developed for decisions about the return of individual results.
Perspective
- Translating the Genomic Architecture of Breast Cancer into Clinical Applications
An objective score of structural alterations in tumor chromosomes gives prognostic information about breast cancer.
Research Articles
- Serotonergic Neurons Mediate Dyskinesia Side Effects in Parkinson’s Patients with Neural Transplants
Two patients with Parkinson’s disease, successfully treated with fetal tissue transplants more than a decade ago, developed troublesome involuntary movements, which could be treated with a serotonin receptor agonist.
- Genomic Architecture Characterizes Tumor Progression Paths and Fate in Breast Cancer Patients
This study demonstrates the relation among structural genomic alterations, molecular subtype, and clinical behavior and shows that an objective score of genomic complexity can provide independent prognostic information in breast cancer.
Editors' Choice
- New Advances in Gene Therapy: The Use of MGMTP140K-Mediated Stem Cell Selection in Nonhuman Primates
In vivo selection with MGMTP140K enhances gene transfer efficiency in nonhuman primates, demonstrating the utility of this system for a variety of human conditions amenable to autologous gene-modified cell therapy.
- Dark Matter Revealed
Rare variants in the sialic acid acetylesterase gene result in substantial risk for common autoimmune conditions.
- Going Organic Yields a Super Model System
A new organ-on-a chip microdevice models the human alveolar-capillary interface—the key functional unit of the living lung—and mimics organ-level functions.
- Sticks and Stones and Mending Bones
Prevascularized bone grafts may speed up bone healing in trauma or fractures with serious complications.
Podcast
- Science Translational Medicine Podcast: 30 June 2010
A conversation with Gary L. Hecimovich and Victoria E. Boegh from Deloitte Tax LLP on the new $1 billion program created by the U.S. Patient Protection and Affordable Care Act.
