23 June 2010
Vol 2, Issue 37

About The Cover

Cover image expansion

ONLINE COVER A Closer Look at Wiskott-Aldrich Syndrome. A differentiating immune T cell carries the protein WASp (green) both in the cytoplasm and the nucleus (blue). When mutated, nuclear WASp causes abnormal immune function in the X-linked childhood disease Wiskott-Aldrich syndrome by disrupting the epigenetic regulation of T helper 1 cell differentiation, as described by Taylor et al. The nucleolus is shown in red. [CREDIT: M. TAYLOR/UNIVERSITY OF PITTSBURG MEDICAL CENTER]