Gene Therapy Takes a Cue from HAART: Combinatorial Antiviral Therapeutics Reach the Clinic

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Science Translational Medicine  16 Jun 2010:
Vol. 2, Issue 36, pp. 36ps30
DOI: 10.1126/scitranslmed.3001298

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For the first time, scientists have tested a combination of three RNA-based gene therapies, delivered via a lentiviral vector, to target HIV in patients. This study not only demonstrates the safety and long-term viability of this approach, but also highlights areas in which focused improvements in gene therapy strategies may provide the most impact in increasingly translating promise in the laboratory to efficacy in the clinic.


  • Citation: P. S. Shah, D. V. Schaffer, Gene therapy takes a cue from HAART: Combinatorial antiviral therapeutics reach the clinic. Sci. Transl. Med. 2, 36ps30 (2010).

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