Stopping Sepsis by Targeting Sphingosine Kinase 1

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Science Translational Medicine  16 Jun 2010:
Vol. 2, Issue 36, pp. 36ps29
DOI: 10.1126/scitranslmed.3001299

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Each year, more than a half million people in the United States alone die from sepsis, a dire multisystem disease with highly inadequate treatment options. In a recent issue of Science, Puneet and colleagues provide compelling evidence that inhibiting sphingosine kinase 1—an enzyme that resides in immune cells and is activated by inflammatory signals—might have great potential as a therapy for septic shock.


  • Citation: L. A. J. O’Neill, Stopping sepsis by targeting sphingosine kinase 1. Sci. Transl. Med. 2, 36ps29 (2010).

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