16 June 2010
Vol 2, Issue 36

About The Cover

Cover image expansion

ONLINE COVER Stopping Sepsis. A dire multisystem disease with limited treatment options, sepsis kills more than a half million people each year in the United States alone. In this week's Perspective by O'Neill, the author discusses a report from a recent issue of Science in which Puneet and colleagues provide compelling evidence that inhibiting host sphingosine kinase 1 might have great potential as a therapy for septic shock. The sphingosine kinase 1 enzyme—whose signaling pathway is shown here—resides in immune cells and is activated by inflammatory signals. The combination of an antibiotic and a sphingosine kinase 1 inhibitor was even more effective as a treatment for sepsis than the inhibitor alone. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]