Contents
Vol 2, Issue 36
Contents
Perspectives
- Stopping Sepsis by Targeting Sphingosine Kinase 1
A recent study suggests that inhibiting the enzyme sphingosine kinase 1 might have great potential as a therapy for sepsis.
- Gene Therapy Takes a Cue from HAART: Combinatorial Antiviral Therapeutics Reach the Clinic
Therapeutic RNAs are stably expressed in blood cells of HIV-positive patients.
Research Article
- RNA-Based Gene Therapy for HIV with Lentiviral Vector–Modified CD34+ Cells in Patients Undergoing Transplantation for AIDS-Related Lymphoma
Transfected stem cells transplanted into patients with HIV infection resulted in sustained RNA expression of introduced genes in blood cells for up to 2 years.
Editors' Choice
- A Key Role for Caveolin
Decreased expression of caveolin-1 causes pathological growth of fibroblasts in idiopathic pulmonary fibrosis.
- Your Brain Controls Your Cholesterol
The brain regulates circulating cholesterol concentrations by controlling hepatic cholesterol clearance.
- Slippery Cargo Ends in Death
A new study suggests that Huntington's disease may involve deficient handling of cargo in macroautophagic vacuoles.
- Hidden in Plain Sight
Ras pathway activation through chromosomal translocations involving RAF defines another group of patients who may benefit from RAF inhibitors.
