Contents
Vol 2, Issue 35
Contents
Commentary
- Reaping the Benefits of Biomedical Research: Partnerships Required
The National Institutes of Health are exploring multiple ways in which to increase the efficiency of the translational process.
Perspective
- On or Off Target: Mutations, Models, and Predictions
An elegant biochemical study reconciles some of the confusing aspects of the discovery and development of anticancer drugs that inhibit the RAF protein kinase.
Research Articles
- Gatekeeper Mutations Mediate Resistance to BRAF-Targeted Therapies
Gatekeeper mutations in BRAF confer drug resistance.
- Systemic Delivery of scAAV9 Expressing SMN Prolongs Survival in a Model of Spinal Muscular Atrophy
An adeno-associated virus vector expressing the survival motor neuron protein rescues mice with spinal muscular atrophy.
Editors' Choice
- What’s Hypusine Got to Do with Diabetes? Well, Maybe a Lot!
Depleting an unusual amino acid found only in a translation initiation factor in islet cells improves β cell function in mice and humans, potentially treating diabetes.
- Blood-Based Diagnostics—A Biopsy Surrogate
A gene-expression profile accurately predicts the risk for transplant rejection.
- Micrometastases + Math = Model of Breast Cancer Dormancy
Mathematical modeling helps predict the extent of dormant breast cancer micrometastases.
- Stretching for Good Blood Vessels
Dynamic stretching improves the mechanical strength of foreign body vascular grafts for potential use in vascular bypass surgery.
