Cystamine Suppresses Polyalanine Toxicity in a Mouse Model of Oculopharyngeal Muscular Dystrophy | Science Translational Medicine

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vol. 2 no. 34 34ra40

DOI:

https://doi.org/10.1126/scitranslmed.3000723

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American Association for the Advancement of Science

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History:

Received for publication December 11, 2009
Accepted for publication May 10, 2010
.

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Copyright © 2010, American Association for the Advancement of Science

Author Information

Janet E. Davies*,
Claudia Rose*,
Sovan Sarkar and
David C. Rubinsztein†

Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0XY, UK.

†To whom correspondence should be addressed. E-mail: dcr1000{at}hermes.cam.ac.uk

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Science Translational Medicine: 2 (34)

Science Translational Medicine

Vol 2, Issue 34
02 June 2010

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Cystamine Suppresses Polyalanine Toxicity in a Mouse Model of Oculopharyngeal Muscular Dystrophy

By Janet E. Davies, Claudia Rose, Sovan Sarkar, David C. Rubinsztein

Science Translational Medicine02 Jun 2010 : 34ra40

Mice with oculopharyngeal muscular dystrophy, caused by aggregation of a nuclear protein, show improvement when treated with cystamine, suggesting a possible therapeutic approach for patients.

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Cystamine Suppresses Polyalanine Toxicity in a Mouse Model of Oculopharyngeal Muscular Dystrophy

By Janet E. Davies, Claudia Rose, Sovan Sarkar, David C. Rubinsztein

Science Translational Medicine02 Jun 2010 : 34ra40

Mice with oculopharyngeal muscular dystrophy, caused by aggregation of a nuclear protein, show improvement when treated with cystamine, suggesting a possible therapeutic approach for patients.

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