02 June 2010
Vol 2, Issue 34

About The Cover

Cover image expansion

ONLINE COVER Weaker and Weaker. A cross-section of biceps muscle from mice carrying the mutation for oculopharyngeal muscular dystrophy, in which toxic aggregated proteins build up in and destroy muscle cells. The protein cytochrome c (red), usually located around the edges of muscle fibers, becomes diffuse in dying cells as it is released from its customary location on the mitochondrial membrane. Treatment with cystamine inhibits the enzyme responsible for creating the protein aggregates. (See Davies et al.) [CREDIT: J. DAVIES]