Research ArticleHIV/AIDS

Tryptophan Catabolism by Indoleamine 2,3-Dioxygenase 1 Alters the Balance of TH17 to Regulatory T Cells in HIV Disease

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Science Translational Medicine  19 May 2010:
Vol. 2, Issue 32, pp. 32ra36
DOI: 10.1126/scitranslmed.3000632

Article Information

vol. 2 no. 32 32ra36

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication November 13, 2009
  • Accepted for publication April 30, 2010
  • .

Author Information

  1. David Favre1,*,
  2. Jeff Mold1,*,
  3. Peter W. Hunt2,
  4. Bittoo Kanwar1,3,
  5. P’ng Loke1,,
  6. Lillian Seu1,
  7. Jason D. Barbour2,
  8. Margaret M. Lowe1,
  9. Anura Jayawardene4,
  10. Francesca Aweeka4,
  11. Yong Huang5,
  12. Daniel C. Douek6,
  13. Jason M. Brenchley7,
  14. Jeffrey N. Martin8,
  15. Frederick M. Hecht2,
  16. Steven G. Deeks2 and
  17. Joseph M. McCune1,§
  1. 1Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA 94110, USA.
  2. 2HIV/AIDS Program, Department of Medicine, University of California, San Francisco, CA 94110, USA.
  3. 3Division of Gastroenterology, Department of Pediatrics, University of California, San Francisco, CA 94110, USA.
  4. 4Drug Research Unit, Department of Clinical Pharmacy, University of California, San Francisco, CA 94143, USA.
  5. 5Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94143, USA.
  6. 6Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  7. 7Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
  8. 8Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143, USA.
  1. §To whom correspondence should be addressed. E-mail: mike.mccune{at}ucsf.edu

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