Contents
Vol 2, Issue 31
Contents
Editorial
- Targeting Cell Metabolism in Cancer Patients
Dichloroacetate can safely modify glucose metabolism in aggressive brain tumors when administered to patients.
Perspectives
- Targeting Myeloid Leukemia Stem Cells
Recently described cell surface molecules that are selectively expressed on leukemia stem cells may pave the way for antibody-based diagnostics or therapeutics.
- Function Follows Form: Defining Mammary Stem Cells
Functional isolation of normal mammary stem cells offers molecular insights into these cells and their cancerous counterparts.
Research Articles
- Spectral Responses of the Human Circadian System Depend on the Irradiance and Duration of Exposure to Light
Light resets the circadian clock through a non–image-forming receptor system—or so it was thought; now, cone photoreceptors are shown to also participate.
- Metabolic Modulation of Glioblastoma with Dichloroacetate
Dichloroacetate, an inhibitor of pyruvate dehydrogenase kinase, shifts metabolism away from aerobic glycolysis in glioblastoma tumor cells and may have clinical efficacy in patients.
Editors' Choice
- Taking Out the Trash
Activation of long-term repeat promoters restores oncogene expression and promotes survival of Hodgkin’s lymphoma.
- Too Much ROCK Is Bad for the Brain
A pathway that regulates the actin cytoskeleton is hyperactivated in a disorder associated with leaky blood vessels.
- Phase 2B Clinical Trials—A Useful Interim Step to a Phase 3 Clinical Trial
Moving to a phase 2B instead of a phase 3 study is useful except in cases when the pretest plausibility of treatment success is extremely high.
- Stopping Cancer in Its Tracks
Combination therapy with TRAIL and all-trans-retinyl acetate prevents the progression of premalignant intestinal polyps into colon cancer.
