Figures
Fig. 1. Drug discovery R&D paradigm. For a more detailed version of this figure, see the supporting online material.
CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE
Tables
- Table 1. Illustrative examples of academic labs that are contributing to the drug discovery process.
IDs, infectious diseases; CVs, cardiovascular diseases.
Institution Illustrative disease focus Areas of basic research and drug discovery Disease biology/gene discovery Chemical biology/pathways Disease target identification Drug target identification Drug target validation Development of assays to screen compounds High-throughput screening Identification of chemical hits and leads Lead testing in animal models SAR/lead optimization Preclinical candidate identification Clinical candidate selection Dose range-finding toxicology Phase I Phase II Phase III Broad Institute Aging, cancer, diabetes, IDs * * * * * * * * * * * * Burnham Institute Cancer, diabetes, obesity * * * * * * * * * * * * Cal Tech Addiction * * * * * Case Western Reserve Cancer * * * * * * * * * * * Columbia U. Cancer, CVs, neurological diseases, IDs * * * * * * * * * Duke U. Aging, cancer * * * * * * * * * * * * * * Emory U. Cancer, IDs, inflammation * * * * * * * * * * * * Georgetown U. Cancer * * * * * * Harvard U. Cancer, CVs, NDDs * * * * * * * * * * * * Memorial Sloan-Kettering Cancer * * * * * * * * * * MIT Aging, cancer * * * * * Mt. Sinai Cancer * * * * * * * * * * * Northwestern U. Cancer * * * * * Ohio State U. Cancer * * * * * * * * * * * * * * Purdue U. Cancer * * * * * * * Rockefeller U. Cancer, obesity * * * * * Scripps Institute Cancer, CVs, immune diseases, IDs * * * * * * * * * Stanford U. Cancer, others * * * * * * * * * * U. of Chicago Cancer * * * * * * U. of Cincinnati Cancer, diabetes, obesity * * * * * * * * U. of Colorado Pain/general * * * U. of Georgia Cancer, IDs * * * * U. of Kansas Cancer * * * * * * * * * * * * * U. of Michigan Alzheimer’s disease, cancer, diabetes * * * * * * * U. of Minnesota Cancer * * * * * * * * * * * U. of North Carolina Cancer * * * * * U. of Pensylvania Cancer * * * * * * * * U. of Pittsburgh Orphan/neglected diseases * * * * * * * * * * U. of Texas Southwestern CVs, neurogenesis * * * * * * * U. of Utah Cancer * * * * U. of Washington Cancer * * * * U. of Wisconsin IDs * * * * * * * UC Berkeley AIDS, cancer, diabetes, IDs * * * * * * UC Los Angeles Aging, diabetes, obesity * * * * * * * * * UC San Diego Pediatric diseases * * * * UC San Francisco Cancer, CVs, immune diseases, IDs, metabolic diseases, NDDs * * * * * * * * * * * * * * * UC Santa Cruz Cancer, viral * * * Vanderbilt U. Cancer, obesity * * * * * * Washington U. Aging, cancer * * * * *
- Supplementary Material for:
Driving Drug Discovery: The Fundamental Role of Academic Labs
B. Michael Silber
E-mail: msilber{at}ind.ucsf.edu
Published 05 May 2010, Sci. Transl. Med.2, 30cm16 (2010)
DOI: 10.1126/scitranslmed.3000169This PDF file includes:
- Fig. S1
