Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth

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  Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth

  By David A. Stoltz, David K. Meyerholz, Alejandro A. Pezzulo, Shyam Ramachandran, Mark P. Rogan, Greg J. Davis, Robert A. Hanfland, Chris Wohlford-Lenane, Cassie L. Dohrn, Jennifer A. Bartlett, George A. Nelson IV, Eugene H. Chang, Peter J. Taft, Paula S. Ludwig, Mira Estin, Emma E. Hornick, Janice L. Launspach, Melissa Samuel, Tatiana Rokhlina, Philip H. Karp, Lynda S. Ostedgaard, Aliye Uc, Timothy D. Starner, Alexander R. Horswill, Kim A. Brogden, Randall S. Prather, Sandra S. Richter, Joel Shilyansky, Paul B. McCray, Jr., Joseph Zabner, Michael J. Welsh

  Science Translational Medicine28 Apr 2010 : 29ra31

  The lungs of just-born piglets with cystic fibrosis fail to efficiently eliminate bacteria, suggesting that lung problems in cystic fibrosis patients may be secondary to impaired antibacterial defense mechanisms.

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  Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth

  By David A. Stoltz, David K. Meyerholz, Alejandro A. Pezzulo, Shyam Ramachandran, Mark P. Rogan, Greg J. Davis, Robert A. Hanfland, Chris Wohlford-Lenane, Cassie L. Dohrn, Jennifer A. Bartlett, George A. Nelson IV, Eugene H. Chang, Peter J. Taft, Paula S. Ludwig, Mira Estin, Emma E. Hornick, Janice L. Launspach, Melissa Samuel, Tatiana Rokhlina, Philip H. Karp, Lynda S. Ostedgaard, Aliye Uc, Timothy D. Starner, Alexander R. Horswill, Kim A. Brogden, Randall S. Prather, Sandra S. Richter, Joel Shilyansky, Paul B. McCray, Jr., Joseph Zabner, Michael J. Welsh

  Science Translational Medicine28 Apr 2010 : 29ra31

  The lungs of just-born piglets with cystic fibrosis fail to efficiently eliminate bacteria, suggesting that lung problems in cystic fibrosis patients may be secondary to impaired antibacterial defense mechanisms.

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