28 April 2010
Vol 2, Issue 29
  • Contents

    • Commentary

    • Perspective

    • Research Articles

      • Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth

        The lungs of just-born piglets with cystic fibrosis fail to efficiently eliminate bacteria, suggesting that lung problems in cystic fibrosis patients may be secondary to impaired antibacterial defense mechanisms.

    • Editors' Choice

      • Keep Monkeying Around

        Induced pluripotent stem cells from nonhuman primates can be used as a model of autologous cell therapy.

      • A BRCA3 Gene?

        Protein-altering variants in the newly designated oncogene, RAD51C, confers substantial risk for developing gynecologic malignancies in a study of 1100 pedigrees with breast and ovarian cancer.

      • What to Ingest When You’re Expecting

        High doses of antioxidant vitamins may not prevent complications from pregnancy-associated high blood pressure.

About The Cover

Cover image expansion

ONLINE COVER Obstructed Airways. This image of lung tissue from a pig with cystic fibrosis captures the early havoc wrought by the disease. The circular airway in the center and the smaller bronchioles at the upper and lower right are completely clogged with immune cells (neutrophils). Surrounding them is the lacey pattern created by the aveoli, the site where gas exchanges with the blood. The oblong blood vessel at the center and the small vessel at the upper left are filled, at this point, with red blood cells. See the paper by Stolz et al. and accompanying Perspective by Wine. [CREDIT: DAVID MEYERHOLZ]