21 April 2010
Vol 2, Issue 28

About The Cover

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ONLINE COVER Epigenetic Gyrations Cause Drug Resistance. Deciphering why some cancer cells become resistant to selected therapeutics is a crucial issue in clinical oncology. In this week's Perspective, Hoey describes recent results that highlight mechanisms at work in drug-resistant subpopulations of cancer cells. The new data reveal that epigenetic changes at the chromatin level control drug sensitivity, providing insight into more effective strategies for treating cancer with combination therapies. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]