Contents
Vol 2, Issue 28
Contents
Commentary
- Refocusing the War on Cancer: The Critical Role of Personalized Treatment
Because a given type of cancer generally represents a collection of diverse disorders, the right treatment must be matched to the right patient to optimize patient outcomes.
Perspective
- Drug Resistance, Epigenetics, and Tumor Cell Heterogeneity
Acquisition of drug resistance can occur through changes at the chromatin level in subpopulations of cancer cells and thus is linked to heterogeneity within tumors.
Research Articles
- Lentiviral Overexpression of GRK6 Alleviates l-Dopa–Induced Dyskinesia in Experimental Parkinson’s Disease
G protein–coupled receptor kinase 6, which promotes desensitization of the dopamine receptor, alleviates dyskinesia without compromising the antiparkinsonian effect of l-dopa.
- Brief Suppression of Abcc8 Prevents Autodestruction of Spinal Cord After Trauma
Secondary injury that occurs after trauma to the spinal cord can be prevented by inhibiting expression of the gene that regulates a cation transporter.
Editors' Choice
- Itraconazole: From Histoplasmosis to Hedgehog Signaling
The antifungal itraconazole inhibits Hedgehog signaling and growth of Hedgehog signaling–dependent tumors.
- You Are What She Ate
Too little protein in the diet of pregnant mice may result in feeding and exercise abnormalities in the offspring that cause adult obesity and diabetes.
- A New Look at Longitudinal Data
A Bayesian approach to longitudinal data analysis offers flexibility in modeling complex subject-to-subject variation.
- The New "Fingerprint": Bacteria on Your Skin
Skin-associated bacterial communities hold promise for forensic identification.
