14 April 2010
Vol 2, Issue 27

About The Cover

Cover image expansion

ONLINE COVER The multitasking pancreas. Pictured here is an islet of Langerhans, an endocrine cell cluster in the pancreas that secretes four different hormones, which perform a multitude of functions. It's no wonder then, that diabetes—which manifests when the pancreas doesn't produce enough insulin—has been a difficult disease to dominate. This week's Perspective by Brown and Edelman wrestles with whether an artificial pancreas—described in the Research Article by El-Khatib et al.—can do the job of the real thing and control blood sugar as effectively as a multipronged approach to diabetes treatment that places the patient at the reins. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]