Contents
Vol 2, Issue 25
Contents
Commentary
- Complexity in Common Diseases: Big Biology for All
Discovery of diagnostic tools and treatments for common human diseases requires integrating research in academic and industrial institutions.
Perspective
- Toward an Oligonucleotide Therapy for Duchenne Muscular Dystrophy: A Complex Development Challenge
By correcting the reading frame in mutant DMD genes, antisense oligonucleotides can restore the production of missing dystrophin protein, but several difficulties must be overcome before such drugs are broadly useful.
Research Articles
- Isolation and Characterization of Circulating Tumor Cells from Patients with Localized and Metastatic Prostate Cancer
Automated imaging of prostate-specific cancer cells from the blood provides a measure of circulating tumor cell half-life after tumor resection.
- Plasmacytoid Dendritic Cells Delineate Immunogenicity of Influenza Vaccine Subtypes
Rare, circulating dendritic cells differentially shape the immunogenicity mechanisms for protection against H1N1 influenza.
Editors' Choice
- Giving Tumors the Silent Treatment
Systemic delivery of siRNA via nanoparticles selectively silences genes in cancer cells from patients with melanoma.
- A Little Estrogen Goes a Long Way
Short-term estrogen treatment in "postmenopausal" rats benefits cognition comparably to long-term estrogen therapy.
- Keep Walking
Proximity to parks and paths is associated with an increased probability of walking in older men.
- Tumor Imaging: Surgeons Can Have It All
Tumor visualization with activatable cell-penetrating peptides during surgery allows more complete tumor removal.
