Contents

Contents

• Commentary

  • Complexity in Common Diseases: Big Biology for All

    By John R. Lamb, Neil W. Gibson

    Science Translational Medicine31 Mar 2010 : 25cm11 Full AccessRestricted Access

    Discovery of diagnostic tools and treatments for common human diseases requires integrating research in academic and industrial institutions.

    • Abstract
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• Perspective

  • Toward an Oligonucleotide Therapy for Duchenne Muscular Dystrophy: A Complex Development Challenge

    By Matthew J. A. Wood

    Science Translational Medicine31 Mar 2010 : 25ps15 Full AccessRestricted Access

    By correcting the reading frame in mutant DMD genes, antisense oligonucleotides can restore the production of missing dystrophin protein, but several difficulties must be overcome before such drugs are broadly useful.

    • Abstract
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• Research Articles

  • Isolation and Characterization of Circulating Tumor Cells from Patients with Localized and Metastatic Prostate Cancer

    By Shannon L. Stott, Richard J. Lee, Sunitha Nagrath, Min Yu, David T. Miyamoto, Lindsey Ulkus, Elizabeth J. Inserra, Matthew Ulman, Simeon Springer, Zev Nakamura, Alessandra L. Moore, Dina I. Tsukrov, Maria E. Kempner, Douglas M. Dahl, Chin-Lee Wu, A. John Iafrate, Matthew R. Smith, Ronald G. Tompkins, Lecia V. Sequist, Mehmet Toner, Daniel A. Haber, Shyamala Maheswaran

    Science Translational Medicine31 Mar 2010 : 25ra23 Full AccessRestricted Access

    Automated imaging of prostate-specific cancer cells from the blood provides a measure of circulating tumor cell half-life after tumor resection.

    • Editor's Summary
    • Abstract
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  • Plasmacytoid Dendritic Cells Delineate Immunogenicity of Influenza Vaccine Subtypes

    By Shohei Koyama, Taiki Aoshi, Takeshi Tanimoto, Yutaro Kumagai, Kouji Kobiyama, Takahiro Tougan, Kazuo Sakurai, Cevayir Coban, Toshihiro Horii, Shizuo Akira, Ken J. Ishii

    Science Translational Medicine31 Mar 2010 : 25ra24 Full AccessRestricted Access

    Rare, circulating dendritic cells differentially shape the immunogenicity mechanisms for protection against H1N1 influenza.

    • Editor's Summary
    • Abstract
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• Editors' Choice

  • Giving Tumors the Silent Treatment

    By Joshi Alumkal

    Science Translational Medicine31 Mar 2010 : 25ec50 Full AccessRestricted Access

    Systemic delivery of siRNA via nanoparticles selectively silences genes in cancer cells from patients with melanoma.

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  • A Little Estrogen Goes a Long Way

    By Rhonda Bentley-Lewis

    Science Translational Medicine31 Mar 2010 : 25ec51 Full AccessRestricted Access

    Short-term estrogen treatment in "postmenopausal" rats benefits cognition comparably to long-term estrogen therapy.

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  • Keep Walking

    By Nichole Carlson

    Science Translational Medicine31 Mar 2010 : 25ec52 Full AccessRestricted Access

    Proximity to parks and paths is associated with an increased probability of walking in older men.

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  • Tumor Imaging: Surgeons Can Have It All

    By Elaine Cheng

    Science Translational Medicine31 Mar 2010 : 25ec53 Full AccessRestricted Access

    Tumor visualization with activatable cell-penetrating peptides during surgery allows more complete tumor removal.

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