24 March 2010
Vol 2, Issue 24
  • Contents

    • Commentary

      • Taking Risks with Translational Research

        The private sector should undertake the high-throughput elements of translational research, while the public sector funds the development of scientists with the confidence to attempt to translate genetic data into a mechanistic understanding of complex diseases.

    • Perspective

      • H1N1: Can a Pandemic Cycle Be Broken?

        The 2009 influenza pandemic initially surprised us, but the lessons it has taught about viral evolution and herd immunity may prepare us for future pandemics.

    • Research Articles

    • Editors' Choice

      • Some Rozi for CF Too!

        PPARγ agonist rosiglitazone reverses inflammation and mucus retention in CF mice models.

      • Don't Forget Your Glia

        The amyloid-β peptide implicated in Alzheimer’s disease has deleterious effects on astrocyte metabolism that in turn depress neuronal viability.

      • The Enemy Within

        Collagen-secreting cells in kidney fibrosis may be derived from microvascular pericytes in the stroma rather than through an epithelial-to-mesenchymal transition.

About The Cover

Cover image expansion

ONLINE COVER A flexible circuit, rolled up and ready to go. A transparent catheter tube used to access the interior of the human body contains a rolled electrode array embedded in bendable plastic. With built-in amplifiers and multiplexers, these flexible electrodes can adhere directly to the surface of wet, mobile tissue and monitor small biological currents. Among other applications, catheter-based delivery of these circuits to the heart could allow high-resolution mapping of cardiac tissue damage for diagnosis and repair. See report by Viventi et al. [CREDIT: D.-H. KIM]