Contents
Vol 2, Issue 23
Contents
Perspectives
- Finding New Cures for Neurological Disorders: A Possible Fringe Benefit of Biodefense Research?
Drugs developed to treat exposure to toxic chemicals might help cure conditions such as stroke, epilepsy, and neurodegenerative diseases.
- Stiff and Tight Skin: A Rear Window into Fibrosis Without Inflammation
Mutations in the fibrillin-1 gene that cause a rare congenital form of scleroderma called stiff skin syndrome shed light on a common fibrotic condition, systemic sclerosis.
Research Articles
- Targeting Robo4-Dependent Slit Signaling to Survive the Cytokine Storm in Sepsis and Influenza
Blunting increased vascular permeability caused by an infection-induced cytokine storm with a Slit ligand increased survival in rodent models of sepsis and viral infection.
- Mutations in Fibrillin-1 Cause Congenital Scleroderma: Stiff Skin Syndrome
Stiff skin syndrome, an autosomal dominant congenital form of scleroderma, is caused by mutations in the domain of fibrillin-1 that mediates integrin binding.
Editors' Choice
- Decoding Neurologic Disorders with Whole-Genome Sequencing
A next-generation sequencing approach identifies two single nucleotide variants in the gene SH3TCT that contribute to Charcot-Marie-Tooth susceptibility.
- Bitter Melon: Adding Zing to Breast Cancer Treatment
Extracts of a bitter melon reduce tumor growth in breast cancer cells.
- Playing Without Pain—Or Tumors
Stem-cell differentiation before therapeutic implantation may be key in reducing the risk of tumor formation and metastatic cancer.
- Protein Cocktail Nourishes New Vessels
Cytokine-packed microparticles prompt a burst of blood vessel growth when mixed with cells in a gel.
