Contents
Vol 2, Issue 22
Contents
Commentary
- The Road We Must Take: Multidisciplinary Team Science
Solutions to today's complex health problems will require multidisciplinary innovative thinking and collaboration.
Perspective
- Bladder Cancer: Optimal Application of Preclinical Models to Suitable Translational Questions
New diagnostic and therapeutic reagents can be tested in bladder cancer xenografts, allowing better economy and focus in clinical cancer trials.
Research Article
- MHC Heterozygote Advantage in Simian Immunodeficiency Virus–Infected Mauritian Cynomolgus Macaques
This manuscript demonstrates unambiguous major histocompatibility complex heterozygote advantage in macaque monkeys infected with the same strain of simian immunodeficiency virus, suggesting that a prophylactic HIV vaccine should elicit a population of CD8+ T cells with broad specificity.
Editors' Choice
- EZ(H2) Does It!
EZH2 repression of the DAB2IP gene that modulates the Ras and NFΚB pathways provides mechanistic insights into metastasis of prostate cancer cells and how this process may be targeted.
- Restoration of Function by Gene Induction
Certain thyroid cancer cells can again take up radioactive iodine after selective gene stimulation.
- Making the Most of Genetic Data from Association Studies
A statistical model for combining data collected under different study designs allows for the detection of new genetic and environmental correlates of disease.
- Is a Painless Labor Possible?
Chemical permeation enhancers increase the effectiveness of lidocaine derivatives, conferring prolonged analgesia without motor impairment.
