10 March 2010
Vol 2, Issue 22
  • Contents

    • Commentary

    • Perspective

    • Research Article

      • MHC Heterozygote Advantage in Simian Immunodeficiency Virus–Infected Mauritian Cynomolgus Macaques

        This manuscript demonstrates unambiguous major histocompatibility complex heterozygote advantage in macaque monkeys infected with the same strain of simian immunodeficiency virus, suggesting that a prophylactic HIV vaccine should elicit a population of CD8+ T cells with broad specificity.

    • Editors' Choice

      • EZ(H2) Does It!

        EZH2 repression of the DAB2IP gene that modulates the Ras and NFΚB pathways provides mechanistic insights into metastasis of prostate cancer cells and how this process may be targeted.

      • Restoration of Function by Gene Induction

        Certain thyroid cancer cells can again take up radioactive iodine after selective gene stimulation.

      • Is a Painless Labor Possible?

        Chemical permeation enhancers increase the effectiveness of lidocaine derivatives, conferring prolonged analgesia without motor impairment.

About The Cover

Cover image expansion

ONLINE COVER A macaque monkey, SIV, and the immune system. This monkey illustrates the model system used by O'Connor et al. in their Research Article to evaluate the contribution of immune response diversity to control of SIV infection, the monkey version of HIV. The ability of an individual monkey to mount a broad immune response against multiple parts of the virus determines its capacity to control the viral infection. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]