Research ArticleRetinal Disease

Safety and Efficacy of Subretinal Readministration of a Viral Vector in Large Animals to Treat Congenital Blindness

See allHide authors and affiliations

Science Translational Medicine  03 Mar 2010:
Vol. 2, Issue 21, pp. 21ra16
DOI: 10.1126/scitranslmed.3000659

Article Information

vol. 2 no. 21 21ra16

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received November 20, 2009
  • Accepted February 9, 2010
  • .

Author Information

  1. Defne Amado1,*,
  2. Federico Mingozzi2,*,
  3. Daniel Hui2,
  4. Jeannette L. Bennicelli1,
  5. Zhangyong Wei1,
  6. Yifeng Chen2,3,
  7. Erin Bote4,
  8. Rebecca L. Grant4,
  9. Jeffrey A. Golden5,6,
  10. Kristina Narfstrom7,
  11. Nasreen A. Syed8,
  12. Stephen E. Orlin9,
  13. Katherine A. High2,3,
  14. Albert M. Maguire1,2 and
  15. Jean Bennett1,2,
  1. 1F. M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
  2. 2Center for Cellular and Molecular Therapeutics, Children’s Hospital of Philadelphia, Abramson Pediatric Research Center, Philadelphia, PA 19014, USA.
  3. 3Howard Hughes Medical Institute, Philadelphia, PA 19104, USA.
  4. 4Nonhuman Primate Research Program, University of Pennsylvania, Department of Pathology and Laboratory Medicine, Gene Therapy Program, Translational Research Laboratories, Philadelphia, PA 19104-3402, USA.
  5. 5Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  6. 6Developmental Biology Program for Pediatric Disorders, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  7. 7College of Veterinary Medicine and Mason Eye Institute, University of Missouri-Columbia, Columbia, MO 65212, USA.
  8. 8Departments of Ophthalmology and Visual Sciences and Pathology, University of Iowa, Iowa City, IA 52242-1007, USA.
  9. 9Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
  1. To whom correspondence should be addressed. E-mail: jebennet{at}mail.med.upenn.edu

Altmetric

Article usage

Article usage: March 2010 to October 2019

AbstractFullPdf
Mar 20105614170183
Apr 20106212348
May 20102984130
Jun 20102921221
Jul 2010156412
Aug 2010211916
Sep 20101582320
Oct 2010137410
Nov 2010139615
Dec 201092412
Jan 201110476
Feb 2011105812
Mar 2011104616
Apr 2011101718
May 201173510
Jun 2011332910
Jul 201113667
Aug 201112166
Sep 201196412
Oct 201187513
Nov 201186411
Dec 20116928
Jan 20125424
Feb 2012182811
Mar 2012147511
Apr 20128546
May 20128713
Jun 20126654
Jul 20124923
Aug 20124947
Sep 201280712
Oct 20125693
Nov 20128063
Dec 2012761812
Jan 201376713
Feb 201372107
Mar 201360410
Apr 20136487
May 20139531
Jun 2013110710
Jul 20135284
Aug 20138544
Sep 20136969
Oct 20136965
Nov 20134235
Dec 20135442
Jan 20144574
Feb 20145469
Mar 20145057
Apr 201417368
May 2014143147
Jun 2014104126
Jul 20145167
Aug 20147693
Sep 20145253
Oct 20146566
Nov 20145031
Dec 20144913
Jan 201561514
Feb 20152957
Mar 20154042
Apr 20154387
May 20153343
Jun 20156573
Jul 20152346
Aug 20152513
Sep 20153113
Oct 20152104
Nov 20151036
Dec 20151710
Jan 20164913
Feb 20163814
Mar 20166412
Apr 20163327
May 20164114
Jun 20169111
Jul 20165030
Aug 20165048
Sep 20169622
Oct 201665011
Nov 20165043
Dec 20164021
Jan 20174325
Feb 20174659
Mar 20177027
Apr 20176516
May 20175512
Jun 20172902
Jul 20175617
Aug 20175128
Sep 20174547
Oct 20174949
Nov 20174224
Dec 20175856
Jan 20184867
Feb 20183111
Mar 20183954
Apr 20184854
May 20186249
Jun 20186436
Jul 20183930
Aug 20182841
Sep 20184363
Oct 20186183
Nov 20188252
Dec 20185253
Jan 201954177
Feb 20195495
Mar 20194265
Apr 20192886
May 20192984
Jun 20192996
Jul 20192042
Aug 201917122
Sep 201924125
Oct 2019020