03 March 2010
Vol 2, Issue 21

About The Cover

Cover image expansion

ONLINE COVER Repeat performance, rave reviews. Last year, a research team from The Children's Hospital of Philadelphia and the University of Pennsylvania used gene therapy to partially restore visual function to one eye in each of 12 patients with a progressive retinal degenerative condition. In this week's issue, the team describes experimental findings that move patients a step closer to the same sight-restoring treatment for their second eyes. Amado et al. show that second-eye readministration of the gene therapy procedure is safe and effective in two large animal models, even in subjects that display preexisting immunity to the vector. These results suggest that a patient who has undergone the therapy in one eye may indeed enjoy success from a second surgery. [CREDIT: PHOTOS.COM]