Contents
Vol 2, Issue 21
Contents
Perspectives
- Fighting Back: Peptidomimetics as a New Weapon in the Battle Against Antibiotic Resistance
An academic institution and a small company team up to develop a new peptidomimetic antibiotic that kills Pseudomonas sp. by targeting its outer-membrane synthesis.
- Of Mice and Men: How an Oncogene Transgresses the Limits and Predisposes to T Cell Acute Lymphoblastic Leukemia
The Lmo2 oncogene confers self-renewal potential on nonrenewing thymocyte progenitors.
Research Articles
- Safety and Efficacy of Subretinal Readministration of a Viral Vector in Large Animals to Treat Congenital Blindness
After successful gene therapy to correct retinal degeneration in one eye, treatment of the second eye is safe and effective—even when immunity to the vector is present—in nonhuman primates and dogs.
- Blood Gene Expression Signatures Predict Invasive Candidiasis
Development and validation of a blood gene expression signature to diagnose C. albicans bloodstream infection.
Editors' Choice
- Emerging Targets
Adenosine signaling and metabolism are altered in chronic airway diseases, suggesting targets for intervention.
- Building Better Bones
Inhibition of serotonin synthesis in the gut leads to an increase in bone mass and may represent an anabolic treatment for osteoporosis.
- Nurturing the Impulse to Supersize
Consumption of high-fat food affects neurotrophic factors in the brain’s reward system, triggering consumption of more high-fat food.
- The Double Life of RAF
Drugs that inhibit RAF kinase in cancer cells show success in the clinic. But how exactly do they work?
- Retinal Stem Cells: Eye Know Where to Go
Floating in a damage-repairing carrier, retinal stem cells that were transplanted into mice eyes integrated properly and adopted the native morphology.
