24 February 2010
Vol 2, Issue 20

About The Cover

Cover image expansion

ONLINE COVER Personalized Analysis of Rearranged Ends (PARE). This multi-armed probe forms the basis of the sequencing technology used to rapidly detect the genetic signatures of individual cancers as reported in this week's Research Article by Leary et al. and discussed in the accompanying Perspective by Prokunina-Olsson and Chanock. PARE is able to accurately discern incorrectly fused genes within an individual's cancer cells from accessible biological fluids, forming an individualized barcode of aberrations. This technology springs cancer therapy closer toward the goal of achieving a personalized, reliable, and cost-effective method for cancer detection and follow-up. [CREDIT: COURTESY OF LIFE TECHNOLOGIES AND DIGIZYME, INC.]