Contents
Vol 2, Issue 20
Contents
Perspectives
- Adipose Tissue Macrophages: A Piece of the PAI of Metabolic Syndrome
Adipose tissue macrophages may link cardiovascular disease and diabetes via the dynamic production of plasminogen activator inhibitor–1.
- Cancer Sequencing Gets a Little More Personal
Using sophisticated sequencing methods, scientists have begun to catalog genetic fusions in cancer genomes, only to find that most changes are unique to an individual tumor and few are common to many.
Research Articles
- Development of Personalized Tumor Biomarkers Using Massively Parallel Sequencing
Rapid detection of specific aberrant rearrangements in tumors from individuals yields a well-poised technological advance toward personalized oncology.
- Adipocyte-Derived Factors Potentiate Nutrient-Induced Production of Plasminogen Activator Inhibitor–1 by Macrophages
In response to free fatty acids and factors from fat cells, macrophages within the fat tissue of obese individuals release a hormone that contributes to atherosclerosis and insulin resistance.
Editors' Choice
- It’s Not My Fault, I Was Born This Way
Prenatal exposure to androgens affects fetal metabolic programming and reproductive health.
- Genetic Risk Scores for Heart Disease: Useful or Useless?
A measure of risk for heart disease calculated from all 101 associated SNPs in the literature cannot predict disease any better than the traditional clinical risk factors.
- Persistent Stuttering: Finding the Key to the Riddle
Defects in lysosomal targeting signals underlie a genetic form of stuttering in a large Pakistani family.
- Let There Be Light: Next-Generation Artificial Corneas
An artificial cornea that restores both innervation and optical function in guinea pigs may one day eliminate the shortage of donor corneas, making routine corneal transplant possible.
