Ten Years of the Immune Tolerance Network: An Integrated Clinical Research Organization

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Science Translational Medicine  17 Feb 2010:
Vol. 2, Issue 19, pp. 19cm7
DOI: 10.1126/scitranslmed.3000672


  • Fig. 1. The collaborative infrastructure for ITN-conducted clinical trials.

    The development, implementation, followup, and analysis of each ITN clinical trial are achieved through a wide-ranging collaboration that includes specialized ITN staff, NIAID regulatory and support staff, dedicated contract research organization (CRO) staff, and academic investigators and advisors who guide the study.



  • Table 1. The ITN by the numbers.


    18 centralized, standardized core assay facilities
    28 clinical trials completed or in progress; 8 in development; 6 in the pipeline
    85 published manuscripts, 3 published in the New England Journal of Medicine; 132 meeting presentations
    125+ full-time employees dedicated to the ITN
    257 concept proposals received since 1999
    167 active clinical sites
    5865+ people participated in ITN trials
    25,000+ assays performed by ITN cores
    370,000+ clinical specimens stored in the ITN repository

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