Contents

Contents

• Commentary

  • Bioethical and Clinical Dilemmas of Direct-to-Consumer Personal Genomic Testing: The Problem of Misattributed Equivalence

    By Charis Eng, Richard R. Sharp

    Science Translational Medicine03 Feb 2010 : 17cm5 Full AccessRestricted Access

    What are the challenges associated with direct-to-consumer genomic tests as compared with validated clinical genetic tests?

    • Abstract
    • Full Text
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• Perspective

  • Engineered Proteins Pull Double Duty

    By Jennifer R. Cochran

    Science Translational Medicine03 Feb 2010 : 17ps5 Full AccessRestricted Access

    Bi-specific proteins that recognize two different clinical targets are starting to enter clinical testing for a variety of biomedical applications.

    • Abstract
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• Research Articles

  • Identification of Therapeutic Targets for Quiescent, Chemotherapy-Resistant Human Leukemia Stem Cells

    By Yoriko Saito, Hiroshi Kitamura, Atsushi Hijikata, Mariko Tomizawa-Murasawa, Satoshi Tanaka, Shinsuke Takagi, Naoyuki Uchida, Nahoko Suzuki, Akiko Sone, Yuho Najima, Hidetoshi Ozawa, Atsushi Wake, Shuichi Taniguchi, Leonard D. Shultz, Osamu Ohara, Fumihiko Ishikawa

    Science Translational Medicine03 Feb 2010 : 17ra9 Full AccessRestricted Access

    CD32 and CD25, molecules specifically found in human leukemia stem cells, are promising targets for therapy.

    • Editor's Summary
    • Abstract
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  • Inducing CTLA-4–Dependent Immune Regulation by Selective CD28 Blockade Promotes Regulatory T Cells in Organ Transplantation

    By Nicolas Poirier, Agnes M. Azimzadeh, Tianshu Zhang, Nahzli Dilek, Caroline Mary, Bao Nguyen, Xavier Tillou, Guosheng Wu, Karine Reneaudin, Jeremy Hervouet, Bernard Martinet, Flora Coulon, Emma Allain-Launay, Georges Karam, Jean-Paul Soulillou, Richard N. Pierson III, Gilles Blancho, Bernard Vanhove

    Science Translational Medicine03 Feb 2010 : 17ra10 Full AccessRestricted Access

    An improved method of immunosuppression allows better immune function and prolongs the survival of transplanted organs in nonhuman primates.

    • Editor's Summary
    • Abstract
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• Editors' Choice

  • Moms and the Metabolic Syndrome

    By Andrew A. Bremer

    Science Translational Medicine03 Feb 2010 : 17ec16 Full AccessRestricted Access

    A new study investigates the effects of caloric restriction of mothers during breast-feeding on the metabolic phenotype of offspring.

    • Full Text

  • Quieting the Quivering Heart

    By Samir Damani

    Science Translational Medicine03 Feb 2010 : 17ec17 Full AccessRestricted Access

    Genome-wide association studies link phenotypes from electrocardiograms with genetic variations, illuminating pathways associated with atrial fibrillation.

    • Full Text

  • Ovarian Cancer Going Viral

    By Donna E. Hansel

    Science Translational Medicine03 Feb 2010 : 17ec18 Full AccessRestricted Access

    Use of the measles virus may provide a new treatment option for patients with recurrent ovarian cancer.

    • Full Text

  • Growing Blood Vessels in Cardiac Grafts

    By Kenneth W. Ng

    Science Translational Medicine03 Feb 2010 : 17ec19 Full AccessRestricted Access

    Tissue patches for injured hearts develop more blood vessels if they are made from both cardiac and vascular precursor cells.

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