Contents
Vol 2, Issue 17
Contents
Commentary
- Bioethical and Clinical Dilemmas of Direct-to-Consumer Personal Genomic Testing: The Problem of Misattributed Equivalence
What are the challenges associated with direct-to-consumer genomic tests as compared with validated clinical genetic tests?
Perspective
- Engineered Proteins Pull Double Duty
Bi-specific proteins that recognize two different clinical targets are starting to enter clinical testing for a variety of biomedical applications.
Research Articles
- Identification of Therapeutic Targets for Quiescent, Chemotherapy-Resistant Human Leukemia Stem Cells
CD32 and CD25, molecules specifically found in human leukemia stem cells, are promising targets for therapy.
- Inducing CTLA-4–Dependent Immune Regulation by Selective CD28 Blockade Promotes Regulatory T Cells in Organ Transplantation
An improved method of immunosuppression allows better immune function and prolongs the survival of transplanted organs in nonhuman primates.
Editors' Choice
- Moms and the Metabolic Syndrome
A new study investigates the effects of caloric restriction of mothers during breast-feeding on the metabolic phenotype of offspring.
- Quieting the Quivering Heart
Genome-wide association studies link phenotypes from electrocardiograms with genetic variations, illuminating pathways associated with atrial fibrillation.
- Ovarian Cancer Going Viral
Use of the measles virus may provide a new treatment option for patients with recurrent ovarian cancer.
- Growing Blood Vessels in Cardiac Grafts
Tissue patches for injured hearts develop more blood vessels if they are made from both cardiac and vascular precursor cells.
