PerspectiveInfectious Disease

Pathogen Microevolution in High Resolution

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Science Translational Medicine  27 Jan 2010:
Vol. 2, Issue 16, pp. 16ps4
DOI: 10.1126/scitranslmed.3000713

Figures

  • Fig. 1. Phylogeography of methicillin-resistant S. aureus strain ST239.

    A map showing the geographical spread of MRSA ST239 as deduced by Harris et al. (6).

    CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE
  • Fig. 2. Bidimensional model of a microbial pathogen variome.

    The variome of S. aureus and other pathogens can be conceptualized in a bidimensional architecture consisting of vertical and horizontal gene pools. The central cylinder represents the core genome and its somehow steady temporal evolution. Phylogenies and typing methods based on core genome elements (for example, restriction fragment length polymorphism and MLST) reflect only the vertical evolution of the species, whereas elements of the accessory genomes (green halo) can produce more rapid evolutionary leaps via horizontal gene transfer. Both genomic dimensions need to be taken into consideration to produce accurate, clinically relevant phylogenies. Arrows reflect continuous bidirectional genetic exchange between the core and accessory gene pools.

    CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE

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