Contents
Vol 2, Issue 16
Contents
Commentary
- Transforming Medicine via Digital Innovation
The newfound ability to monitor physiological metrics digitally via non-invasive wireless sensors, along with genome-wide scanning and whole-genome sequencing, should lead to an extraordinary accrual of physiological and biological data about individuals.
Perspective
- Pathogen Microevolution in High Resolution
The application of next-generation high-throughput genotyping technologies, as illustrated in a recent analysis of a highly resistant Staphylococcus aureus strain, can provide new clues on the geographical origin and intrahospital spread of important microbial pathogens.
Research Articles
- Resiliency and Vulnerability in the HER2-HER3 Tumorigenic Driver
The ability of certain breast cancers to resist a tyrosine kinase inhibitor drug may be overcome with high intermittent doses.
- Metabolomic Imaging for Human Prostate Cancer Detection
Magnetic resonance spectroscopy can generate comprehensive maps of metabolites in the prostate that reveal cancerous regions, potentially guiding biopsies and prognosis.
Editors' Choice
- DAMD to Do Better!
DAMD, a high-throughput platform for assessing DNA methylation changes, provides new insights into the development and treatment of pediatric brain tumors.
- Which Came First?
Researchers use Mendelian randomization to decipher directions of causality between obesity and inflammation.
- Accounting for Participant Dropout in Clinical Studies
A statistical model for longitudinal data can account for subjects that drop out of the study, avoiding biases in the conclusions.
- Obesity and Inflammation: The Fas Connection
The death receptor Fas may contribute to obesity-induced inflammation and the pathogenesis of type 2 diabetes mellitus.