Contents

Contents

• Commentary

  • Transforming Medicine via Digital Innovation

    By Eric J. Topol

    Science Translational Medicine27 Jan 2010 : 16cm4 Full AccessRestricted Access

    The newfound ability to monitor physiological metrics digitally via non-invasive wireless sensors, along with genome-wide scanning and whole-genome sequencing, should lead to an extraordinary accrual of physiological and biological data about individuals.

    • Abstract
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• Perspective

  • Pathogen Microevolution in High Resolution

    By Ramy K. Aziz, Victor Nizet

    Science Translational Medicine27 Jan 2010 : 16ps4 Full AccessRestricted Access

    The application of next-generation high-throughput genotyping technologies, as illustrated in a recent analysis of a highly resistant Staphylococcus aureus strain, can provide new clues on the geographical origin and intrahospital spread of important microbial pathogens.

    • Abstract
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• Research Articles

  • Resiliency and Vulnerability in the HER2-HER3 Tumorigenic Driver

    By Dhara N. Amin, Natalia Sergina, Deepika Ahuja, Martin McMahon, Jimmy A. Blair, Donghui Wang, Byron Hann, Kevin M. Koch, Kevan M. Shokat, Mark M. Moasser

    Science Translational Medicine27 Jan 2010 : 16ra7 Full AccessRestricted Access

    The ability of certain breast cancers to resist a tyrosine kinase inhibitor drug may be overcome with high intermittent doses.

    • Editor's Summary
    • Abstract
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  • Metabolomic Imaging for Human Prostate Cancer Detection

    By Chin-Lee Wu, Kate W. Jordan, Eva M. Ratai, Jinhua Sheng, Christen B. Adkins, Elita M. DeFeo, Bruce G. Jenkins, Leslie Ying, W. Scott McDougal, Leo L. Cheng

    Science Translational Medicine27 Jan 2010 : 16ra8 Full AccessRestricted Access

    Magnetic resonance spectroscopy can generate comprehensive maps of metabolites in the prostate that reveal cancerous regions, potentially guiding biopsies and prognosis.

    • Editor's Summary
    • Abstract
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• Editors' Choice

  • DAMD to Do Better!

    By Joshi Alumkal

    Science Translational Medicine27 Jan 2010 : 16ec12 Full AccessRestricted Access

    DAMD, a high-throughput platform for assessing DNA methylation changes, provides new insights into the development and treatment of pediatric brain tumors.

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  • Which Came First?

    By Rhonda Bentley-Lewis

    Science Translational Medicine27 Jan 2010 : 16ec13 Full AccessRestricted Access

    Researchers use Mendelian randomization to decipher directions of causality between obesity and inflammation.

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  • Accounting for Participant Dropout in Clinical Studies

    By Nichole Carlson

    Science Translational Medicine27 Jan 2010 : 16ec14 Full AccessRestricted Access

    A statistical model for longitudinal data can account for subjects that drop out of the study, avoiding biases in the conclusions.

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  • Obesity and Inflammation: The Fas Connection

    By Elaine Cheng

    Science Translational Medicine27 Jan 2010 : 16ec15 Full AccessRestricted Access

    The death receptor Fas may contribute to obesity-induced inflammation and the pathogenesis of type 2 diabetes mellitus.

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