Why Most Gene Expression Signatures of Tumors Have Not Been Useful in the Clinic

See allHide authors and affiliations

Science Translational Medicine  13 Jan 2010:
Vol. 2, Issue 14, pp. 14ps2
DOI: 10.1126/scitranslmed.3000313

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


Omics technologies are expected to enhance our understanding of a variety of diseases and to open the door to patient-specific personalized medicine. Despite the extensive literature on the use of gene expression arrays to predict prognosis in cancer patients, poor progress has been made in the translation of gene expression signatures for use in the clinics. Breast cancer provides a ripe arena for an analysis of why such signatures have failed to fulfill their promise.


  • Citation: S. Koscielny, Why most gene expression signatures of tumors have not been useful in the clinic. Sci. Transl. Med. 2, 14ps2 (2010).

View Full Text

Stay Connected to Science Translational Medicine