Contents
Vol 2, Issue 14
Contents
Commentary
- Translational Medicine Policy Issues in Infectious Disease
Analysis from the European Academies Science Advisory Council is used to explore policy issues for R&D funding priorities and the environment for innovation in Europe.
Perspective
- Why Most Gene Expression Signatures of Tumors Have Not Been Useful in the Clinic
Breast cancer provides a ripe arena for an analysis of why gene signatures devised from microarray data have failed to fulfill their promise.
Research Articles
- Uncovering Residual Effects of Chronic Sleep Loss on Human Performance
The cumulative effects of chronic sleep loss may be overcome at certain times of day, but the residual effects of sleep deprivation profoundly degrade performance and may thereby compromise safety.
- Intermittent Prophylaxis with Oral Truvada Protects Macaques from Rectal SHIV Infection
Treating monkeys with single doses of an antiretroviral drug before and after exposure to SHIV provides protection against infection, a schedule that may prove practical in humans.
Editors' Choice
- Mechanism of a Metabolic Shift in Monkeys
A new study investigates the mechanistic effects of fetal glucocorticoid exposure on metabolic syndrome in primates.
- Bone Metastases in Prostate Cancer: Finding the Achilles' Heel
A study in humanized mice reveals a strong dependence of bone-associated human prostate cancer cells on IGF-II, a possible therapeutic target.
- Decoding Renal Cell Carcinoma
Deep sequencing unveils unchartered links to the etiology of kidney cancer.
- Longer-Lived Proteins
A new method for extending the half-life of therapeutic proteins may open the door for reduced drug dosing as well as new peptide pharmaceuticals.