Contents

Contents

• Commentary

  • Translational Medicine Policy Issues in Infectious Disease

    By Robin Fears, Jos W. M. van der Meer, Volker ter Meulen

    Science Translational Medicine13 Jan 2010 : 14cm2 Full AccessRestricted Access

    Analysis from the European Academies Science Advisory Council is used to explore policy issues for R&D funding priorities and the environment for innovation in Europe.

    • Abstract
    • Full Text
    • PDF

• Perspective

  • Why Most Gene Expression Signatures of Tumors Have Not Been Useful in the Clinic

    By Serge Koscielny

    Science Translational Medicine13 Jan 2010 : 14ps2 Full AccessRestricted Access

    Breast cancer provides a ripe arena for an analysis of why gene signatures devised from microarray data have failed to fulfill their promise.

    • Abstract
    • Full Text
    • PDF

• Research Articles

  • Uncovering Residual Effects of Chronic Sleep Loss on Human Performance

    By Daniel A. Cohen, Wei Wang, James K. Wyatt, Richard E. Kronauer, Derk-Jan Dijk, Charles A. Czeisler, Elizabeth B. Klerman

    Science Translational Medicine13 Jan 2010 : 14ra3 Full AccessRestricted Access

    The cumulative effects of chronic sleep loss may be overcome at certain times of day, but the residual effects of sleep deprivation profoundly degrade performance and may thereby compromise safety.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • Intermittent Prophylaxis with Oral Truvada Protects Macaques from Rectal SHIV Infection

    By J. Gerardo García-Lerma, Mian-er Cong, James Mitchell, Ae S. Youngpairoj, Qi Zheng, Silvina Masciotra, Amy Martin, Zsuzsanna Kuklenyik, Angela Holder, Jonathan Lipscomb, Chou-Pong Pau, John R. Barr, Debra L. Hanson, Ron Otten, Lynn Paxton, Thomas M. Folks, Walid Heneine

    Science Translational Medicine13 Jan 2010 : 14ra4 Full AccessRestricted Access

    Treating monkeys with single doses of an antiretroviral drug before and after exposure to SHIV provides protection against infection, a schedule that may prove practical in humans.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Editors' Choice

  • Mechanism of a Metabolic Shift in Monkeys

    By Andrew A. Bremer

    Science Translational Medicine13 Jan 2010 : 14ec4 Full AccessRestricted Access

    A new study investigates the mechanistic effects of fetal glucocorticoid exposure on metabolic syndrome in primates.

    • Full Text

  • Bone Metastases in Prostate Cancer: Finding the Achilles' Heel

    By Donna E. Hansel

    Science Translational Medicine13 Jan 2010 : 14ec5 Full AccessRestricted Access

    A study in humanized mice reveals a strong dependence of bone-associated human prostate cancer cells on IGF-II, a possible therapeutic target.

    • Full Text

  • Decoding Renal Cell Carcinoma

    By Samir Damani

    Science Translational Medicine13 Jan 2010 : 14ec6 Full AccessRestricted Access

    Deep sequencing unveils unchartered links to the etiology of kidney cancer.

    • Full Text

  • Longer-Lived Proteins

    By Kenneth W. Ng

    Science Translational Medicine13 Jan 2010 : 14ec7 Full AccessRestricted Access

    A new method for extending the half-life of therapeutic proteins may open the door for reduced drug dosing as well as new peptide pharmaceuticals.

    • Full Text