Research ArticleMalaria

The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance

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Science Translational Medicine  21 Jul 2021:
Vol. 13, Issue 603, eabg6013
DOI: 10.1126/scitranslmed.abg6013

Article Information

vol. 13 no. 603

Print ISSN: 
Online ISSN: 
  • Received for publication January 15, 2021
  • Accepted for publication July 2, 2021
  • .

Author Information

  1. James M. Murithi1,,
  2. Cécile Pascal2,,,
  3. Jade Bath1,
  4. Xavier Boulenc3,,
  5. Nina F. Gnädig1,
  6. Charisse Flerida A. Pasaje4,
  7. Kelly Rubiano1,
  8. Tomas Yeo1,
  9. Sachel Mok1,
  10. Sylvie Klieber5,
  11. Paul Desert3,
  12. María Belén Jiménez-Díaz6,
  13. Jutta Marfurt7,
  14. Mélanie Rouillier8,
  15. Mohammed H. Cherkaoui-Rbati8,
  16. Nathalie Gobeau8,
  17. Sergio Wittlin9,10,
  18. Anne-Catrin Uhlemann11,
  19. Ric N. Price7,12,13,
  20. Grennady Wirjanata7,
  21. Rintis Noviyanti14,
  22. Patrick Tumwebaze15,
  23. Roland A. Cooper16,
  24. Philip J. Rosenthal17,
  25. Laura M. Sanz18,
  26. Francisco Javier Gamo18,
  27. Jayan Joseph19,
  28. Shivendra Singh19,
  29. Sridevi Bashyam19,
  30. Jean Michel Augereau2,§,
  31. Elie Giraud2,,
  32. Tanguy Bozec2,,
  33. Thierry Vermat2,,
  34. Gilles Tuffal5,
  35. Jean-Michel Guillon2,
  36. Jérôme Menegotto2,,
  37. Laurent Sallé5,
  38. Guillaume Louit20,
  39. Marie-José Cabanis5,
  40. Marie Françoise Nicolas20,
  41. Michel Doubovetzky2,
  42. Rita Merino2,||,
  43. Nadir Bessila2,,
  44. Iñigo Angulo-Barturen6,
  45. Delphine Baud8,
  46. Lidiya Bebrevska8,
  47. Fanny Escudié8,,
  48. Jacquin C. Niles4,
  49. Benjamin Blasco8,#,
  50. Simon Campbell8,
  51. Gilles Courtemanche21,
  52. Laurent Fraisse2,,
  53. Alain Pellet2,,
  54. David A. Fidock1,11,* and
  55. Didier Leroy8,*
  1. 1Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
  2. 2Sanofi, Infectious Diseases Therapeutic Area, Marcy l’Etoile, France.
  3. 3Sanofi Pasteur, Marcy L’Etoile, France.
  4. 4Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
  5. 5Sanofi R&D, Translational Medicine & Early Development, Montpellier, France.
  6. 6The Art of Discovery, Bizkaia, Basque Country, Spain.
  7. 7Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia.
  8. 8Medicines for Malaria Venture, Geneva, Switzerland.
  9. 9Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.
  10. 10Universität Basel, Basel, Switzerland.
  11. 11Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
  12. 12Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  13. 13Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
  14. 14Eijkman Institute for Molecular Biology, Jakarta, Indonesia.
  15. 15Infectious Diseases Research Collaboration, Kampala, Uganda.
  16. 16Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, CA, USA.
  17. 17Department of Medicine, University of California, San Francisco, CA, USA.
  18. 18Global Health Pharma Research Unit, GSK, Tres Cantos, Madrid, Spain.
  19. 19Syngene International Ltd., Bangalore, India.
  20. 20Sanofi, Vitry-sur-Seine, France.
  21. 21Bioaster, Paris, France.
  1. *Corresponding author. Email: df2260{at} (D.A.F.); leroyd{at} (D.L.)
  • These authors contributed equally to this work as co–first authors.

  • Present address: Evotec Infectious Diseases, Marcy L’Etoile, France.

  • § Present address: LCC-CNRS, 205 Route de Narbonne, 31400 Toulouse, France.

  • || In memoriam.

  • Present address: Drugs for Neglected Diseases initiative, Geneva, Switzerland.

  • # Present address: Global Antibiotic Research and Development Partnership, Geneva, Switzerland.


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