Research ArticlePharmacogenomics

Toward predicting CYP2D6-mediated variable drug response from CYP2D6 gene sequencing data

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Science Translational Medicine  21 Jul 2021:
Vol. 13, Issue 603, eabf3637
DOI: 10.1126/scitranslmed.abf3637

Article Information

vol. 13 no. 603

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication October 23, 2020
  • Resubmitted January 11, 2021
  • Accepted for publication June 14, 2021
  • .

Author Information

  1. Maaike van der Lee1,2,
  2. William G. Allard3,4,
  3. Rolf H. A. M. Vossen3,4,
  4. Renée F. Baak-Pablo1,
  5. Roberta Menafra3,4,
  6. Birgit A. L. M. Deiman5,
  7. Maarten J. Deenen1,6,
  8. Patrick Neven7,
  9. Inger Johansson8,
  10. Stefano Gastaldello8,
  11. Magnus Ingelman-Sundberg8,
  12. Henk-Jan Guchelaar1,2,
  13. Jesse J. Swen1,2,* and
  14. Seyed Yahya Anvar1,2,3,4,*,
  1. 1Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
  2. 2Leiden Network for Personalised Therapeutics, 2333 ZA Leiden, Netherlands.
  3. 3Department of Human Genetics, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
  4. 4Leiden Genome Technology Center, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
  5. 5Clinical Laboratory, Catharina Hospital Eindhoven, 5623 EJ Eindhoven, Netherlands.
  6. 6Department of Clinical Pharmacy, Catharina Hospital Eindhoven, 5623 EJ Eindhoven, Netherlands.
  7. 7University Hospital Leuven, 3000 Leuven, Belgium.
  8. 8Department of Physiology and Pharmacology, Karolinska Institutet, Biomedicum 5B, 171 77 Solna, Sweden.
  1. *Corresponding author. Email: j.j.swen{at}lumc.nl (J.J.S); yahya.anvar{at}okra.ai (S.Y.A.)
  • Present address: OKRA Technologies, CB4 0WS Cambridge, UK.

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