Research ArticleCancer

A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice

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Science Translational Medicine  21 Jul 2021:
Vol. 13, Issue 603, eabf1383
DOI: 10.1126/scitranslmed.abf1383

Article Information

vol. 13 no. 603

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication October 6, 2020
  • Accepted for publication July 1, 2021
  • .

Author Information

  1. Matthew W. Boudreau1,2,,
  2. Darjan Duraki3,,
  3. Lawrence Wang3,
  4. Chengjian Mao3,
  5. Ji Eun Kim3,
  6. Madeline A. Henn4,
  7. Bingtao Tang4,
  8. Sean W. Fanning5,,
  9. Jeffrey Kiefer6,
  10. Theodore M. Tarasow6,
  11. Elizabeth M. Bruckheimer6,
  12. Ramon Moreno6,
  13. Spyro Mousses6,
  14. Geoffrey L. Greene5,
  15. Edward J. Roy4,7,
  16. Ben Ho Park8,
  17. Timothy M. Fan2,4,7,9,
  18. Erik R. Nelson2,4,7,10,11,
  19. Paul J. Hergenrother1,2,7,* and
  20. David J. Shapiro3,7,*
  1. 1Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  2. 2Carl R. Woese Institute for Genomic Biology University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  3. 3Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  4. 4Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  5. 5Ben May Department of Cancer Research, University of Chicago, Chicago, IL 60637, USA.
  6. 6Systems Oncology, Scottsdale, AZ 85255, USA.
  7. 7Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  8. 8Department of Medicine, Division of Heme/Onc, Vanderbilt Ingram Cancer Center, Nashville, TN 37232, USA.
  9. 9Department of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.
  10. 10Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  11. 11University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA.
  1. *Corresponding author. Email: djshapir{at}illinois.edu (D.J.S.); hergenro{at}illinois.edu (P.J.H.)
  • These authors contributed equally to this work.

  • Present address: Department of Cancer Biology, Loyola University Chicago, Maywood, IL 60153, USA.

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