Research ArticleCancer

A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice

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Science Translational Medicine  21 Jul 2021:
Vol. 13, Issue 603, eabf1383
DOI: 10.1126/scitranslmed.abf1383

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Beating back breast cancer

Estrogen receptor–positive breast cancer is the most common type of breast cancer and, in its metastatic form, is currently incurable. In a new study, Boudreau et al. describe a compound, ErSO, that can activate the unfolded protein response, resulting in necrosis of human breast cancer cell lines in vitro. In vivo, this treatment induced complete regression of cell line and patient-derived orthotopic and metastatic breast cancer xenografts in mice. The authors showed that this treatment was well tolerated in mice, rats, and dogs and could provide a new avenue of intervention for this deadly disease.

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