Research ArticleCardiovascular Disease

Dynamic loading of human engineered heart tissue enhances contractile function and drives a desmosome-linked disease phenotype

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Science Translational Medicine  21 Jul 2021:
Vol. 13, Issue 603, eabd1817
DOI: 10.1126/scitranslmed.abd1817

Article Information

vol. 13 no. 603

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication June 5, 2020
  • Accepted for publication July 2, 2021
  • .

Author Information

  1. Jacqueline M. Bliley1,,
  2. Mathilde C. S. C. Vermeer2,,
  3. Rebecca M. Duffy1,
  4. Ivan Batalov1,
  5. Duco Kramer3,
  6. Joshua W. Tashman1,
  7. Daniel J. Shiwarski1,
  8. Andrew Lee1,
  9. Alexander S. Teplenin4,
  10. Linda Volkers4,
  11. Brian Coffin5,
  12. Martijn F. Hoes2,
  13. Anna Kalmykov1,
  14. Rachelle N. Palchesko1,
  15. Yan Sun1,
  16. Jan D. H. Jongbloed6,
  17. Nils Bomer2,
  18. Rudolf A. de Boer2,
  19. Albert J. H. Suurmeijer7,
  20. Daniel A. Pijnappels4,
  21. Maria C. Bolling8,
  22. Peter van der Meer2,* and
  23. Adam W. Feinberg1,5,*
  1. 1Regenerative Biomaterials and Therapeutics Group, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
  2. 2Department of Cardiology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
  3. 3Department of Dermatology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
  4. 4Department of Cardiology, Heart Lung Center Leiden, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
  5. 5Department of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
  6. 6Department of Genetics, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
  7. 7Department of Pathology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
  8. 8Department of Dermatology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
  1. *Corresponding author. Email: feinberg{at}andrew.cmu.edu (A.W.F.); p.van.der.meer{at}umcg.nl (P.v.d.M.)
  • These authors contributed equally to this work.

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