Research ArticleAortic aneurysm

Erythropoietin promotes abdominal aortic aneurysms in mice through angiogenesis and inflammatory infiltration

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Science Translational Medicine  21 Jul 2021:
Vol. 13, Issue 603, eaaz4959
DOI: 10.1126/scitranslmed.aaz4959

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Erythropoietin and AAA

Abdominal aortic aneurysm (AAA) is a common vascular disease, but its pathogenesis has not been fully elucidated. Here, Zhang and colleagues developed a murine model of AAA by administering high doses of erythropoietin, which led to aneurysm formation regardless of ApoE status or angiotensin II infusion, unlike the commonly used murine AAA model. Endothelial cells were critical to erythropoietin’s effects on the aorta, and JAK2/STAT5 pathway activation was implicated in this process. The authors also found a correlation between erythropoietin concentrations and AAA in patients, suggesting that the link between erythropoietin and AAA deserves further investigation in humans.

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