21 July 2021
Vol 13, Issue 603

About The Cover

Cover image expansion

ONLINE COVER Malaria Drug Momentum. This image shows human red blood cells infected with Plasmodium falciparum in which parasites have developed into immature (ring stage) or mature trophozoites. Murithi et al. identified and characterized an acylguanidine compound, MMV688533, which had potent antimalarial activity against multiple P. falciparum strains and favorable pharmacokinetic and toxicity profiles. MMV688533 treatment was associated with the development of low-grade resistance, although parasites resistant to MMV688533 were still sensitive to existing antimalarial drugs. These results highlight MMV688533 as a promising antimalarial candidate that merits further study. [CREDIT: BOBBI S. PRITT, MAYO CLINIC]