07 July 2021
Vol 13, Issue 601

About The Cover

Cover image expansion

ONLINE COVER Mimicking Ciliary Flow. Shown is an airway organoid generated from human-derived induced pluripotent stem cells (iPSCs) where red indicates HEATR2, white indicates acetylated tubulin, and blue indicates nuclei. Understanding the mechanisms mediating airway ciliary function in health and disease has been hindered by the paucity of models recapitulating mucociliary flow. By combining iPSCs and airway-on-a-chip technology, Sone et al. emphasized the critical relevance of fluid shear stress in regulating mucociliary flow. Using iPSCs from a patient with primary ciliary dyskinesia (PCD), the authors were able to replicate ciliary flow dysfunction observed in vivo. This airway-on-a-chip model will be useful to study the mechanisms mediating PCD. [CREDIT: SONE ET AL./SCIENCE TRANSLATIONAL MEDICINE]