30 June 2021
Vol 13, Issue 600

About The Cover

Cover image expansion

ONLINE COVER Casting a NET for Cutaneous Adverse Drug Reactions. This electron micrograph shows evidence of neutrophil extracellular trap (NET) formation in skin isolated from a patient with Stevens-Johnson syndrome (SJS) one day after onset. SJS and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions characterized by extensive epidermal detachment. The involvement of CD8+ T cells in SJS and TEN is established, but the role of innate immune cells is unclear. Here, Kinoshita et al. identified a role for neutrophils in SJS and TEN. The authors found that CD8+ T cells induced formation of NETs, which in turn triggered necroptosis and death in keratinocytes. Together, these findings implicate neutrophils in SJS and TEN and suggest that neutrophils could serve as a diagnostic or therapeutic target. [CREDIT: KINOSHITA ET AL./SCIENCE TRANSLATIONAL MEDICINE]