16 June 2021
Vol 13, Issue 598

About The Cover

Cover image expansion

ONLINE COVER Understanding Edema. The image shows a dorsal skin section from a mouse treated with anti-colony-stimulating factor 1 receptor (CSF1R) monoclonal antibodies, revealing increased proliferation (Ki67, green) among CD44-expressing cells (red), such as keratinocytes and fibroblasts. Nuclei are shown in blue. CSF1R blockade, which is approved as a treatment for diffuse-type giant cell tumors, depletes tumor-associated macrophages but can lead to edema formation. Bissinger et al. investigated the mechanism by which CSF1R blockade causes edema, finding that in mice, CSF1R blockade led to an increase in matrix metalloproteases and enhanced deposition of hyaluronan and proteoglycans. Serum hyaluronic acid was elevated in samples from humans treated with the anti-CSF1R antibody emactuzumab, suggesting that it may be a marker for edema development in patients. [CREDIT: BISSINGER ET AL./SCIENCE TRANSLATIONAL MEDICINE]