Research ArticleMalaria

Plasmodium falciparum Pf77 and male development gene 1 as vaccine antigens that induce potent transmission-reducing antibodies

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Science Translational Medicine  09 Jun 2021:
Vol. 13, Issue 597, eabg2112
DOI: 10.1126/scitranslmed.abg2112

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Additional antigens for malaria

Despite extensive research, malaria vaccines that disrupt the Plasmodium life cycle and prevent transmission are lacking. Thus, there is a critical need for new targets for transmission-blocking vaccines (TBVs). Here, Tripathi et al. identified Pf77 and male development gene 1 (PfMDV-1) from Plasmodium falciparum that are expressed at multiple life stages and induce transmission-reducing antibodies when administered to mice. Antibodies targeting Pf77 and PfMDV-1 were also identified in a cohort of adults in Ghana, suggesting that targeting these antigens may induce durable immune responses in humans. Together, Pf77 and PfMDV-1 merit further evaluation as TBV candidates.

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