Research ArticleLIVER INJURY

Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury

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Science Translational Medicine  09 Jun 2021:
Vol. 13, Issue 597, eaba8146
DOI: 10.1126/scitranslmed.aba8146

Article Information

vol. 13 no. 597

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication January 7, 2020
  • Resubmitted December 18, 2020
  • Accepted for publication April 2, 2021
  • .

Author Information

  1. Anissa A. Widjaja1*,,
  2. Jinrui Dong1,,
  3. Eleonora Adami1,
  4. Sivakumar Viswanathan1,
  5. Benjamin Ng1,2,
  6. Leroy S. Pakkiri3,
  7. Sonia P. Chothani1,
  8. Brijesh K. Singh1,
  9. Wei Wen Lim2,
  10. Jin Zhou1,
  11. Shamini G. Shekeran1,
  12. Jessie Tan1,2,
  13. Sze Yun Lim2,
  14. Joyce Goh1,
  15. Mao Wang1,
  16. Robert Holgate4,
  17. Arron Hearn4,
  18. Leanne E. Felkin5,
  19. Paul M. Yen1,
  20. James W. Dear6,
  21. Chester L. Drum7,8,9,
  22. Sebastian Schafer1,2 and
  23. Stuart A. Cook1,2,10,*
  1. 1Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore.
  2. 2National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore 169609, Singapore.
  3. 3Cardiac Department, National University Hospital, Singapore 119074, Singapore.
  4. 4Abzena, Babraham Research Campus, Babraham, Cambridge CB22 3AT, UK.
  5. 5National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
  6. 6Pharmacology, Toxicology and Therapeutics, Centre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4TJ, UK.
  7. 7Cardiovascular Research Institute, National University Health System, Singapore 119228, Singapore.
  8. 8Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
  9. 9Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
  10. 10MRC-London Institute of Medical Sciences, Hammersmith Hospital Campus, London W12 0NN, UK.
  1. *Corresponding author. Email: stuart.cook{at}duke-nus.edu.sg (S.A.C.); anissa.widjaja{at}duke-nus.edu.sg (A.A.W.)
  • These authors contributed equally to this work.

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