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High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages

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Science Translational Medicine  02 Jun 2021:
Vol. 13, Issue 596, eabf8654
DOI: 10.1126/scitranslmed.abf8654

Article Information

vol. 13 no. 596

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History: 
  • Received for publication November 25, 2020
  • Resubmitted March 5, 2021
  • Accepted for publication May 4, 2021
  • .

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Author Information

  1. Willianne Hoepel1,2,,
  2. Hung-Jen Chen3,,
  3. Chiara E. Geyer1,2,
  4. Sona Allahverdiyeva1,2,4,
  5. Xue D. Manz5,
  6. Steven W. de Taeye4,6,7,
  7. Jurjan Aman5,
  8. Lynn Mes1,2,4,
  9. Maurice Steenhuis6,
  10. Guillermo R. Griffith3,
  11. Peter I. Bonta8,
  12. Philip J.M. Brouwer4,
  13. Tom G. Caniels4,
  14. Karlijn van der Straten4,9,
  15. Korneliusz Golebski10,
  16. René E. Jonkers8,
  17. Mads D. Larsen7,
  18. Federica Linty7,
  19. Jan Nouta11,
  20. Cindy P.A.A. van Roomen3,
  21. Frank E.H.P. van Baarle12,
  22. Cornelis M. van Drunen13,
  23. Gertjan Wolbink6,14,
  24. Alexander P.J. Vlaar12,
  25. Godelieve J. de Bree9,
  26. Rogier W. Sanders4,15,
  27. Lisa Willemsen3,
  28. Annette E. Neele3,
  29. Diederik van de Beek16,
  30. Theo Rispens6,
  31. Manfred Wuhrer11,
  32. Harm Jan Bogaard5,
  33. Marit J. van Gils4,
  34. Gestur Vidarsson7,
  35. Menno de Winther3,*, and
  36. Jeroen den Dunnen1,2,*,
  1. 1Department of Rheumatology and Clinical Immunology, Amsterdam UMC, Amsterdam Rheumatology and Immunology Center, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.
  2. 2Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection and Immunity Institute, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.
  3. 3Department of Medical Biochemistry, Experimental Vascular Biology, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.
  4. 4Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection and Immunity Institute, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.
  5. 5Department of Pulmonary Medicine, Amsterdam UMC, location VUMC, De Boelelaan 1117, 1081 HV Amsterdam, Netherlands.
  6. 6Department of Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Centre, Plesmanlaan 125, 1066 CX Amsterdam, Netherlands.
  7. 7Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, Netherlands.
  8. 8Department of Pulmonology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.
  9. 9Department of Internal Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam Infection and Immunity Institute, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.
  10. 10Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.
  11. 11Center for Proteomics and Metabolomics, Leiden University Medical Center, Albinusdreef 2, 2333 AZ Leiden, Netherlands.
  12. 12Department of Intensive Care Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.
  13. 13Department of Otorhinolaryngology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.
  14. 14Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, Reade, Admiraal Helfrichstraat 1, 1056 AA Amsterdam, Netherlands.
  15. 15Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.
  16. 16Departments of Neurology and Neuroscience, University of Amsterdam, Meibergdreef, Amsterdam UMC, Amsterdam, Netherlands.
  1. *Corresponding author. Email: j.dendunnen{at}amsterdamumc.nl (J.d.D.); m.dewinther{at}amsterdamumc.nl (M.d.W.)
  • These authors contributed equally to this work as co–first authors.

  • These authors contributed equally to this work as co–last authors.

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