Research ArticleDEMENTIA

Cis P-tau underlies vascular contribution to cognitive impairment and dementia and can be effectively targeted by immunotherapy in mice

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Science Translational Medicine  02 Jun 2021:
Vol. 13, Issue 596, eaaz7615
DOI: 10.1126/scitranslmed.aaz7615

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A PreCISe therapy for vascular dementia

Vascular contributions to cognitive impairment and dementia (VCID) are conditions arising from vascular diseases or abnormalities that result in cognitive impairments. Unfortunately, the pathophysiology of VCID remains to be elucidated. Now, Qiu et al. used samples from patients with vascular dementia and mouse models to show that cis P-tau was increased in the brain and played a major role in causing cognitive impairments in mice. A cis-specific immunotherapy had therapeutic effects in the rodent models of VCID, whereas soluble cis P-tau administration caused neurodegeneration and brain dysfunction resembling VCID. The results suggest that targeting cis P-tau could reduce memory loss and neurodegeneration in VCID.

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