02 June 2021
Vol 13, Issue 596

About The Cover

Cover image expansion

ONLINE COVER “Head”-ing in the Direction of Vaccination. This image shows the structure of the hemagglutinin (HA) glycoprotein of the A/California/04/2009 strain of influenza. Regions with higher degrees of conservation across strains are colored in darker shades of blue. Conserved regions on the HA head are attractive targets for developing vaccines. Guthmiller et al. found that first exposure to the 2009 pandemic strain of H1N1 elicited memory B cells that targeted two conserved regions of the HA head, the receptor binding site (RBS) and lateral patch. Monoclonal antibodies derived from RBS- or lateral patch-specific B cells were broadly neutralizing in vitro and protective in a mouse model of influenza infection. The authors conclude that vaccine strategies targeting these conserved regions may offer broad protection against influenza virus. [CREDIT: GUTHMILLER ET AL./SCIENCE TRANSLATIONAL MEDICINE]