Research ArticleAlzheimer’s Disease

PAC1 receptor–mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain

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Science Translational Medicine  26 May 2021:
Vol. 13, Issue 595, eaba7394
DOI: 10.1126/scitranslmed.aba7394

Article Information

vol. 13 no. 595

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Online ISSN: 
  • Received for publication January 3, 2020
  • Resubmitted September 22, 2020
  • Accepted for publication January 9, 2021
  • .

Author Information

  1. Ari W. Schaler1,2,
  2. Avery M. Runyan1,2,
  3. Catherine L. Clelland1,2,
  4. Eric J. Sydney1,2,
  5. Stephanie L. Fowler3,
  6. Helen Y. Figueroa1,2,
  7. Seiji Shioda4,
  8. Ismael Santa-Maria1,2,
  9. Karen E. Duff1,2,3 and
  10. Natura Myeku1,2,*
  1. 1Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA.
  2. 2Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
  3. 3U.K. Dementia Research Institute, University College London, London WC1E 6BT, UK.
  4. 4Innovative Drug Discovery, Global Research Center for Innovative Life Science, Hoshi University, Tokyo 142-8501, Japan.
  1. *Corresponding author. Email: nm2631{at}


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