26 May 2021
Vol 13, Issue 595

About The Cover

Cover image expansion

ONLINE COVER Hypersensitivity Channel. The image shows a mouse dorsal root ganglion expressing genes encoding transient receptor potential canonical 5 (TRPC5, red), calcitonin gene–related peptide (green), P2X3 receptor (blue), and neurofilament 200 (cyan). Inflammatory and neuropathic pain are characterized by mechanical allodynia, a painful sensation to an innocuous stimulus. Using multiple models of mechanical allodynia, Sadler et al. found that the activation of TRPC5 expressed in dorsal root ganglia determined mechanical allodynia in mice. Importantly, TRPC5 was expressed also in human dorsal root ganglia, suggesting that TRPC5 inhibitors might be effective in reducing mechanical allodynia in patients. [CREDIT: SADLER ET AL./SCIENCE TRANSLATIONAL MEDICINE]