19 May 2021
Vol 13, Issue 594

About The Cover

Cover image expansion

ONLINE COVER Hungry Macrophages Eat Up Tumors. This image shows macrophages (uncolored) phagocytosing tumor cells (yellow) after treatment with an inhibitor of cIAP1/2 (cellular inhibitor of apoptosis proteins 1 and 2) plus lymphotoxin. Tumor cells are able to go undetected by T cells by losing expression of major histocompatibility complex (MHC) class I molecules. However, there are strategies by which T cells can promote tumor cell killing without direct detection of tumor cells. Roehle et al. demonstrated that treating mice with an inhibitor of cIAP1/2 induced T cells to produce lymphotoxin, which in turn activated macrophages to phagocytose tumor cells. This promoted tumor cell death in vitro and in mouse models in vivo. Thus, cIAP1/2 inhibition may be a therapeutic option for patients with MHC class I–deficient tumors. [CREDIT: ROEHLE ET AL./SCIENCE TRANSLATIONAL MEDICINE]